MONOLIX
(MOdèles NOn LInéaires à effets miXtes) is
a free software dedicated to the analysis of non linear mixed effects
models. The objective of this software is to perform:
1) Parameter estimation
- computing the maximum likelihood estimator of the parameters,
without any approximation of the model
- computing standard errors for the maximum likelihood estimator,
2) Model selection
- comparing several models using some information criteria (AIC,
BIC),
- testing hypotheses using the Likelihood Ratio Test,
- testing parameters using the Wald Test.
3) Goodness of fit plots
4) Data simulation
More information is available
at http://software.monolix.org/sdoms/software/index.php?/objective.html#readmore
This section explains
the procedure to develop a population PK or PKPD model for the problem
given in case studies.
We have assumed the following
things before any user uses this section:
o MONOLIX is installed
on the PC.
A MONOLIX run
requires the following
o Data file : User supplied
text file containing all data for analysis.
o MLXTRAN Code: User-written
and supplied modeling instruction file for MONOLIX. There are
several built-in PK models that can we used without requiring
the user supplied MLXTRAN code
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