Page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 Page 10 Page 11 Page 12 Page 13 Page 14 Page 15 Page 16 Page 17 Page 18 Page 19 Page 20 Page 21 Page 22 Page 23 Page 24 Page 25 Page 26 Page 27 Page 28 Page 29 Page 30 Page 31 Page 32 Page 33 Page 34 Page 35 Page 36 Page 37 Page 38 Page 39 Page 40 Page 41 Page 42 Page 43 Page 44Big Data Emergin Alte Special Populations 24 MONDAY, SEPTEMBER 18, 2017 l Symposium 7 l 8:00 am – 12:00 pm Modeling of Adherence: Applications in Drug Development & Clinical Practice DISCOVERY TRACK CO-CHAIRS: Ayyappa Chaturvedula, PhD, Associate Professor, Univ of North Texas System Coll of Pharmacy Mark Sale, MD, Senior Vice President, Nuventra Pharma Sciences TARGET AUDIENCE: This Symposium will be useful for clinical pharmacologists from academia and the pharmaceutical industry, public health researchers, physicians, pharmacists, pharmacometricians, pharmacokinetic/pharmacodynamic scientists and drug development scientists. GOALS AND OBJECTIVES: Following completion of this activity, the learner will be able to: 1. Compare various objective and subjective measures of adherence in clinical research; 2. Analyze various pharmacometric models for quantifying adherence; 3. Apply quantitative adherence models in clinical trial simulation and patient care. 8:00 – 8:05 am Introduction Ayyappa Chaturvedula, PhD, Associate Professor, Univ of North Texas System Coll of Pharmacy and Mark Sale, MD, Senior Vice President, Nuventra Pharma Sciences 8:05 – 8:45 am Impact of Adherence on the Development of Medications for HIV Pre-exposure Prophylaxis Craig Hendrix, MD, Wellcome Professor & Director, Div of Clinical Pharmacology, Johns Hopkins Univ School of Medicine 8:45 – 9:30 am Collection & Interpretation of Adherence Data for Clinical Care & Intervention Jessica Haberer, MD, MS, Associate Professor, Massachusetts General Hosp & Harvard Medical School 9:30 – 10:00 am / Break 10:00 – 10:40 am Quantifying Adherence: Pharmacometrician’s Perspective Michael J. Fossler, Jr, PharmD, PhD, Vice President, Quantitative Sciences, Travena Inc 10:40 – 11:30 am Application of Quantitative Adherence Models Ene Ette, PhD, President & Chief Executive Officer, Anoixis Corp 11:30 am – 12:00 pm Panel Discussion and Q&A Symposia